原创力文档mono- and combination drug therapies in hospitalized patients with bipolar depression. data from the european drug surveillance program amspmono -组合药物疗法在双相抑郁患者住院。.pdfVIP
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mono- and combination drug therapies in hospitalized patients with bipolar depression. data from the european drug surveillance program amspmono -组合药物疗法在双相抑郁患者住院。
Haeberle et al. BMC Psychiatry 2012, 12:153
/1471-244X/12/153
RESEARCH ARTICLE Open Access
Mono- and combination drug therapies in
hospitalized patients with bipolar depression.
Data from the European drug surveillance
program AMSP
1 1,2* 3 1
Anne Haeberle , Waldemar Greil , Stefan Russmann and Renate Grohmann
Abstract
Background: For the pharmacological treatment of bipolar depression several guidelines exist. It is largely
unknown, to what extent the prescriptions in daily clinical routine correspond to these evidence based
recommendations and which combinations of psychotropic drugs are frequently used.
Methods: The prescriptions of psychotropic drugs were investigated of all in-patients with bipolar depression
(n = 2246; time period 1994–2009) from hospitals participating in the drug surveillance program AMSP. For the drug
use in 2010, 221 cases were analysed additionally.
Results: From 1994 to 2009, 85% of all patients received more than one class of psychotropic substances: 74%
received antidepressants in combination therapy, 55% antipsychotics, 48% anticonvulsants and 33% lithium. When
given in combination, lithium is the most often prescribed substance for bipolar depression (33%), followed by
valproic acid (23%), mirtazapine and venlafaxine (16% each), quetiapine (15%), lamotrigine (14%) and olanzapine
(13%). Both, lithium and valproic acid are often combined with selective serotonin reuptake inhibitors (SSRI), but
also with mirtazapine und venlafaxine. Combinations of more than one antidepressant occur quite often, whereby
combinations with bupropion, paroxetine, fluoxetine or fluvoxamine are very rare. In 2010, quetiapine (alone and
combined) was the most frequently prescribed drug (39%); aripiprazo
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