monocarboxylate transporters and lactate metabolism in equine athletes a reviewmonocarboxylate转运蛋白和乳酸代谢在马运动员进行审查.pdfVIP

Acta vet. scand. 2002, 43, 63-74. Monocarboxylate Transporters and Lactate Metabolism in Equine Athletes: A Review By A. R. Pösö Department of Basic Veterinary Sciences, University of Helsinki, Finland. Pösö AR: Monocarboxylate transporters and lactate metabolism in equine ath- letes: A review. Acta vet. scand. 2002, 43, 63-74. – Lactate is known as the end product of anaerobic glycolysis, a pathway that is of key importance during high inten- sity exercise. Instead of being a waste product lactate is now regarded as a valuable sub- strate that significantly contributes to the energy production of heart, noncontracting muscles and even brain. The recent cloning of monocarboxylate transporters, a con- served protein family that transports lactate through biological membranes, has given a new insight into the role of lactate in whole body metabolism. This paper reviews cur- rent literature on lactate and monocarboxylate transporters with special reference to horses. Horse; MCT; skeletal muscle; Red blood cell; Exercise. Introduction Horses are superb athletes in comparison to tate across biological membranes, has added a other athletic species. Exceptionally high max- new perspective to our knowledge of lactate imal oxygen uptake, a splenic reserve of red metabolism in exercise physiology (Poole blood cells released into the circulation during Halestrap 1996, Halestrap Price 1999). At exercise, and a high amount of energy stored as the moment the physiological importance of glycogen in the muscles contribute to the high these transporters is not completely understood, performance capacity of a horse (Jone