musings on genome medicine crohns disease沉思在基因组医学克隆氏病.pdfVIP

Musings Musings on genome medicine: Crohn’s disease David G Nathan and Stuart H Orkin Address: Dana­Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA. Correspondence: David G Nathan. Email: david_nathan@ occur (or be correctly diagnosed) at any age. The major Abstract symptoms include abdominal pain, diarrhea (occasionally The inflammatory bowel diseases, Crohn’s disease and ulcera­ tive colitis, pose a fascinating challenge to specialists in gastro­ bloody), constipation, vomiting, and weight loss. CD is often enterology, infectious diseases, immunology and genetics and associated with various skin rashes (including erythema an often crushing burden to patients and their families. nodosum), rheumatoid arthritis and uveitis, strongly suggesting an autoimmune basis for the disease to some, but the result of chronic stimulation of cytokine production and Approximately a half million children and adults deal with T cell activation to others. When CD is active, it is usually Crohn’s disease (CD) in North America for a prevalence of associated with microcytic anemia, the so-called ‘anemia of about 170/100,000 [1], while the prevalence averages inflammation’ induced by excessive hepcidin synthesis in about 40/100,000 in Europe [2]. Curiously, the prevalence the liver and resultant inactivation of ferriportin. The latter and incidence are higher in the northern parts of Europe diminishes iron transport