原创力文档morning versus evening dosing of desloratadine in seasonal allergic rhinitis a randomized controlled study [isrctn23032971].早上和晚上剂量的地氯雷他定在季节性过敏性鼻炎随机对照研究[isrctn23032971]。.pdfVIP
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morning versus evening dosing of desloratadine in seasonal allergic rhinitis a randomized controlled study [isrctn23032971].早上和晚上剂量的地氯雷他定在季节性过敏性鼻炎随机对照研究[isrctn23032971]。
Clinical and Molecular Allergy BioMed Central
Research Open Access
Morning versus evening dosing of desloratadine in seasonal allergic
rhinitis: a randomized controlled study [ISRCT.
1 2 3 4 4
Rolf Haye* , Kjetil Høye , Olof Berg , Sissel Frønes and Tone Ødegård
Address: 1Rikshospitalet, 0027 Oslo, Norway, 2Helsetorget Legesenter, 2408 Elverum, Norway, 3Betania, ENT-clinic, 114 38 Stockholm, Sweden
and 4Schering-Plough AS, 1359 Eiksmarka, Norway
Email: Rolf Haye* - rolf.haye@klinmed.uio.no; Kjetil Høye - rolf.haye@klinmed.uio.no; Olof Berg - o.berg@inmanu.se;
Sissel Frønes - sissel.frones@; Tone Ødegård - tone.odegard@
* Corresponding author
Published: 02 February 2005 Received: 28 October 2004
Accepted: 02 February 2005
Clinical and Molecular Allergy 2005, 3:3 doi:10.1186/1476-7961-3-3
This article is available from: /content/3/1/3
© 2005 Haye et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: A circadian rhythm of symptoms has been reported in allergic rhinitis and some
studies have shown the dosing time of antihistamines to be of importance for optimizing symptom
relief in this disease. The objective of this study was to examine the efficacy of morning vs
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