原创力文档intestinal dysbacteriosis induces changes of t lymphocyte subpopulations in peyers patches of mice and orients the immune response towards humoral immunity肠道菌群失调引起的t淋巴细胞亚群变化派尔集合淋巴结的老鼠和方向对体液免疫的免疫反应.pdfVIP
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intestinal dysbacteriosis induces changes of t lymphocyte subpopulations in peyers patches of mice and orients the immune response towards humoral immunity肠道菌群失调引起的t淋巴细胞亚群变化派尔集合淋巴结的老鼠和方向对体液免疫的免疫反应
Gao et al. Gut Pathogens 2012, 4:19
/content/4/1/19
LETTER TO THE EDITOR Open Access
Intestinal dysbacteriosis induces changes of T
lymphocyte subpopulations in Peyer’s patches of
mice and orients the immune response towards
humoral immunity
1 1 1 2 1* 1*
Fei Gao , Ming Li , Yinhui Liu , Chuanzhou Gao , Shu Wen and Li Tang
Abstract
The large numbers of human intestinal microorganisms have a highly co-evolved relationship with the immune
system. Dysbacteriosis of intestinal microbiota induces alterations of immune responses, and is closely related to
disease development. Peyer’s patches are immune sensors in intestine which exert essential functions during
development of inflammatory disease. However, interactions between commensal bacteria and PPs have been
poorly characterized. In this study, changes of lymphocyte subpopulations and production of cytokines in PPs of
mice with intestinal dysbacteriosis were investigated. The ceftriaxone-induced dysbacteriosis caused a notable
change in populations of T lymphocytes, their subpopulations in PPs and expressions of various cytokines. Our
results suggest intestinal dysbacteriosis in mice reduces immune tolerance in PPs and orients immune response
towards humoral immunity.
Keywords: Intestinal dysbacteriosis, Peyer’s patches, Immune response, T lymphocytes, Cytokines
Background reduced immune tolerance, are as yet poorly documen-
Intestinal microorganisms are required for proper devel- ted. Peyer’s patches (PPs) are major component of
opment of the immune system, as indicated by the fact GALT. Lacking of PPs and lymph nodes would develop
that germ-free (GF) mi
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