原创力文档- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
mutagenesis in rodents using the l1 retrotransposon使用l1逆转录转座子突变在啮齿动物
Review
Mutagenesis in rodents using the L1 retrotransposon
†
Eric M Ostertag* , Blair B Madison* and Hiroki Kano*
*University of Pennsylvania School of Medicine, Department of Genetics, Curie Blvd, Philadelphia, Pennsylvania 19104, USA.
†University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, Curie Blvd, Philadelphia, Pennsylvania
19104, USA.
Correspondence: Eric M Ostertag. E-mail: ostertag@
Published: 31 October 2007
Genome Biology 2007, 8(Suppl 1):S16 (doi:10.1186/gb-2007-8-S1-S16)
The electronic version of this article is the complete one and can be
found online at /2007/8/S1/S16
© 2007 BioMed Central Ltd
Abstract
LINE1 (L1) retrotransposons are genetic elements that are present in all mammalian genomes.
L1s are active in both humans and mice, and are capable of copying themselves and inserting the
copy into a new genomic location. These de novo insertions occasionally result in disease.
Endogenous L1 retrotransposons can be modified to increase their activity and mutagenic power
in a variety of ways. Here we outline the advantages of using modified L1 retrotransposons for
performing random mutagenesis in rodents and discuss several potential applications.
Introduction means that the parent element remains in its original genetic
LINE1 (long interspersed nucleotide element 1 [L1]) elements location, and a copy (de novo insertion) is inserted
are important genome modifiers, altering mammalian somewhere else in the genome (as opposed to the ‘cut and
genomes in many ways. L1 elements have contributed to new paste’ mechanism of DNA transposons, in which the paren
您可能关注的文档
- morphinofobia the situation among the general population and health care professionals in north-eastern portugalmorphinofobia之间的情况在葡萄牙东北部的普通人群和健康保健专业人员.pdf
- more than just needles an evidence-informed approach to enhancing harm reduction supply distribution in british columbia不仅仅是针的阐述循证方法提高供应减少危害分布在不列颠哥伦比亚省.pdf
- morphological and molecular characterization of a spontaneously tuberizing potato mutant an insight into the regulatory mechanisms of tuber induction自发tuberizing马铃薯的形态和分子特性突变一个洞察块茎感应的监管机制.pdf
- morphology of the leather defect light flecks and spots形态学的皮革缺陷光斑点,斑点.pdf
- morphology and head morphometric characters of sperm in thai native crossbred stallions精子的形态和头部东海泰国本地杂交马.pdf
- morphometrical analysis of transbronchial cryobiopsiesmorphometrical分析transbronchial cryobiopsies.pdf
- morphological and functional alterations in adult boar epididymis effects of prenatal and postnatal administration of flutamide形态和功能改变在成年野猪附睾flutamide产前及产后管理的影响.pdf
- mortality among us employees of a large computer manufacturing company 1969–2001死亡率在我们员工的大型计算机制造公司1969 - 2001.pdf
- mortality and life expectancy of professional fire fighters in hamburg, germany a cohort study 1950 – 2000死亡率和预期寿命的专业消防队员在汉堡,德国一个队列研究1950 - 2000.pdf
- morphological and molecular characterization of developing vertebral fusions using a teleost model形态学和分子特征发展中使用硬骨鱼椎融合模型.pdf
文档评论（0）