原创力文档mutation at the position 2058 of the 23s rrna as a cause of macrolide resistance in streptococcus pyogenes突变的位置2058 23 s rrna酿脓链球菌引起的大环内酯物抵抗.pdfVIP
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mutation at the position 2058 of the 23s rrna as a cause of macrolide resistance in streptococcus pyogenes突变的位置2058 23 s rrna酿脓链球菌引起的大环内酯物抵抗
Annals of Clinical Microbiology and
Antimicrobials BioMed Central
Research Open Access
Mutation at the position 2058 of the 23S rRNA as a cause of
macrolide resistance in Streptococcus pyogenes
1 2 1
Jari Jalava* , Martti Vaara and Pentti Huovinen
Address: 1Department of Human Microbial Ecology and Inflammation, National Public Health Institute, Kiinamyllynkatu 13, 20520 Turku,
Finland and 2Martti Vaara – Division of Clinical Microbiology, Helsinki University Central Hospital, Haartmaninkatu 4, 00029 Helsinki, Finland
Email: Jari Jalava* - jari.jalava@ktl.fi; Martti Vaara - martti.vaara@helsinki.fi; Pentti Huovinen - pentti.huovinen@ktl.fi
* Corresponding author
Published: 06 May 2004 Received: 19 February 2004
Accepted: 06 May 2004
Annals of Clinical Microbiology and Antimicrobials 2004, 3:5
This article is available from: /content/3/1/5
© 2004 Jalava et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all
media for any purpose, provided this notice is preserved along with the articles original URL.
Abstract
Background: In streptococci, three macrolide resistance determinants (erm(B), erm(TR) and
mef(A)) have been found. In addition, certain mutations at the ribosomal 23S RNA can cause
resistance to macrolides. Mutation at the position 2058 of the 23S rRNA of the Streptococcus
py
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