myocardial segment-specific model generation for simulating the electrical action of the heart心肌segment-specific模型生成模拟心脏的电操作.pdfVIP

BioMedical Engineering OnLine BioMed Central Research Open Access Myocardial segment-specific model generation for simulating the electrical action of the heart Darren A Hooks* Address: Bioengineering Institute, University of Auckland, New Zealand Email: Darren A Hooks* - d.hooks@auckland.ac.nz * Corresponding author Published: 5 June 2007 Received: 19 March 2007 Accepted: 5 June 2007 BioMedical Engineering OnLine 2007, 6:21 doi:10.1186/1475-925X-6-21 This article is available from: /content/6/1/21 © 2007 Hooks; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Computer models of the electrical and mechanical actions of the heart, solved on geometrically realistic domains, are becoming an increasingly useful scientific tool. Construction of these models requires detailed measurement of the microstructural features which impact on the function of the heart. Currently a few generic cardiac models are in use for a wide range of simulation problems, and contributions to publicly accessible databases of cardiac structures, on which models can be solved, remain rare. This paper presents to-date the largest database of porcine left ventricular segment microstructural architecture,