neural mechanisms of subclinical depressive symptoms in women a pilot functional brain imaging study女性亚临床抑郁症状的神经机制试点功能性大脑成像研究.pdfVIP

Felder et al. BMC Psychiatry 2012, 12:152 /1471-244X/12/152 RESEARCH ARTICLE Open Access Neural mechanisms of subclinical depressive symptoms in women: a pilot functional brain imaging study 1,5* 2 2 2 2,4 1,3,4 Jennifer N Felder , Moria J Smoski , Rachel V Kozink , Brett Froeliger , Joseph McClernon , Joshua Bizzell , Christopher Petty4 and Gabriel S Dichter1,2,3,4 Abstract Background: Studies of individuals who do not meet criteria for major depressive disorder (MDD) but with subclinical levels of depressive symptoms may aid in the identification of neurofunctional abnormalities that possibly precede and predict the development of MDD. The purpose of this study was to evaluate relations between subclinical levels of depressive symptoms and neural activation patterns during tasks previously shown to differentiate individuals with and without MDD. Methods: Functional magnetic resonance imaging (fMRI) was used to assess neural activations during active emotion regulation, a resting state scan, and reward processing. Participants were twelve females with a range of depressive symptoms who did not meet criteria for MDD. Results: Increased depressive symptom severity predicted (1) decreased left midfrontal gyrus activation during reappraisal of sad stimuli; (2) increased right midfrontal gyrus activation during distraction from sad stimuli; (3) increased functional connectivity between a precuneus seed region and left orbitofrontal cortex during a resting state scan; and (4) increased paracingulate activation during non-win outcomes during a reward-processing task. Conclusions: These pilot data shed light on relations between subclinical levels of depressive symptoms in