new role for agrin in t cells and its potential importance in immune system regulation微笑的新角色的t细胞及其免疫系统调节的潜在重要性.pdfVIP

Jury and Kabouridis Arthritis Research Therapy 2010, 12:205 /content/12/2/205 R E V I E W New role for Agrin in T cells and its potential importance in immune system regulation 1 2 Elizabeth C Jury* and Panagiotis S Kabouridis* interactions play a critical role in the activation of T cells; Abstract thus, a reduced capability to interact might result in Agrin plays a crucial role in the maintenance of the failure to generate a good response when needed, where- neuromuscular junction. However, it is expressed as increased and/or sustained interaction might result in in other tissues as well, including T lymphocytes, a breach of tolerance against self antigens, leading to the where cell activation induces its expression. Agrin development of autoimmunity. from activated T cells has the capacity to induce h e formation of a mature IS has been characterized aggregation of key receptors and to regulate signalling. recently using advances in imaging techniques [4]. Initial Interestingly, T cells isolated from patients with activation of the TCR leads to the rapid formation of systemic lupus erythematosus over-express Agrin and microclusters that contain phosphorylated-active TCR its co-stimulation with the T cell receptor enhances associated with the proximal signalling proteins Lck, production of pathogenic cytokines. These early ZAP-70 and LAT [5,6]. h ese microclusters are active