new steroidal glycosides isolated as cd40l inhibitors of activated platelets新甾体苷孤立cd40l的抑制剂激活血小板.pdfVIP

Molecules 2010, 15, 4589-4598; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets Haifeng Chen 1, Wenchao Ou 2,*,Guanghui Wang 1, Naili Wang 3, Linnan Zhang 4 and Xinsheng Yao 1,3,* 1 Institute for Biomedical Research, Xiamen University, Xiamen 361005, China; E-Mails: haifeng@ (H.-F.C.); guanghui@ (G.-H.W.) 2 Department of Cardiology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China 3 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China; E-Mail: wangnl@ (N.-L.W.) 4 Clinical Medicine Pharmacy College, China Medical University, Shenyang 110001, China; E-Mail: z.lnn@163.com (L.-N.Z.) ∗ Author to whom correspondence should be addressed; E-Mails: owenc@126.com (W.-C.O.); yaoxinsheng@ (X.-S.Y.); Tel.:+86 Received: 24 April 2010; in revised form: 25 May 2010 / Accepted: 7 June 2010 / Published: 25 June 2010 Abstract: Three new compounds were isolated from the dried bulbs of Allium macrostemon Bunge. Their structures were elucidated from their spectral data as (25R)-26-O-β-D-glucopyranosyl-5α-furostane-3β,12β,22,26-tetraol-3-O-β-D-glucopyranos -yl (1→2) [β-D-glucopyranosyl (1 →3)]-β-D-glucopyranosyl (1 →4)-β-D-galactopyranoside (1), (25R)-26-O-β-D-glucopyranosyl-5α-furostane-3β,12α,22,26-tetraol-3-O-β-D-gluco- pyranosyl (1→2) [β-D-glucopyranosyl (1→3)]-β-D-glucopyranosyl (1 →4)-β-D-galacto- pyranoside (2)