natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome自然杀伤细胞功能障碍是一种特色的系统性幼年型类风湿性关节炎发作和巨噬细胞活化综合征.pdfVIP

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natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome自然杀伤细胞功能障碍是一种特色的系统性幼年型类风湿性关节炎发作和巨噬细胞活化综合征.pdf

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natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome自然杀伤细胞功能障碍是一种特色的系统性幼年型类风湿性关节炎发作和巨噬细胞活化综合征

Available online /content/7/1/R30 Vol 7 No 1 Open Access Research article Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome 1 1 2 2 2 Joyce Villanueva , Susan Lee , Edward H Giannini , Thomas B Graham , Murray H Passo , Alexandra Filipovich1 and Alexei A Grom2 1Division of Hematology/Oncology, Childrens Hospital Medical Center, Cincinnati, Ohio, USA 2William S Rowe Division of Rheumatology, Childrens Hospital Medical Center, Cincinnati, Ohio, USA Corresponding author: Alexei A Grom, groma0@ Received: 13 Jul 2004 Revisions requested: 10 Sep 2004 Revisions received: 21 Sep 2004 Accepted: 27 Sep 2004 Published: 10 Nov 2004 Arthritis Res Ther 2005, 7:R30-R37 (DOI 10.1186/ar1453) /content/7/1/R30 © 2004 Villanueva et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Macrophage activation syndrome (MAS) has been reported in significantly lower in patients with sJRA than in other JRA association with many rheumatic diseases, most commonly in patients and controls. In a subgroup of patients with systemic juvenile rheumatoid arthritis (sJRA). Clinically, MAS is predominantly sJRA