new secoiridoid glycosides from the roots of picrorhiza scrophulariiflora新secoiridoid苷的根源picrorhiza scrophulariiflora.pdfVIP

Molecules 2008, 13, 2049-2057; DOI: 10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 © 2008 by MDPI /molecules Article New secoiridoid Glycosides from the Roots of Picrorhiza Scrophulariiflora Lian-Chun Zou 1,2, Tong-Fei Zhu 2,3, Hua Xiang 2, Lu Yu 2, Zhi-Hui Yan 4, Shu-Cai Gan 1, Da-Cheng Wang 2,*, Sheng Zeng 2 and Xu-Ming Deng 2,* 1 College of Chemistry, Jilin University, Changchun 130062, P.R. China 2 College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, P.R. China; E-mails: xianghuaxh@126.com (Hua Xiang), yulu225@126.com (Lu Yu) 3 Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China 4 Chongqing Medical and Pharmaceutical College, Chongqing 400030, P.R. China * Authors to whom correspondence should be addressed; E-mail: wdc9928@ (Da-Cheng Wang); xumingdeng@ (Xu-Ming Deng); Fax: +86-431-8783-6160. Received: 30 June 2008; in revised form: 27 August 2008 / Accepted: 28 August 2008 / Published: 1 September 2008 Abstract: Three new secoiridoid glycosides, named picrogentiosides A (1), B (2) and C (3), have been isolated from the underground parts of Picrorhiza Scrophulariiflora, together with the two known compounds plantamajoside (4) and plantainoside D (5). Their structures were established by spectroscopic analyses and comparisons with data from related compounds. A pilot pharmacological study showed that picrogentiosides A (1) a