new triterpene diglycosides from the rhizome of cimifuga foetida新三萜烯diglycosides cimifuga麻的粉末.pdfVIP

Molecules 2008, 13, 1712-1721; DOI: 10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /molecules Article New Triterpene Diglycosides from the Rhizome of Cimifuga foetida Lirong Sun 1, Jian Yan 1,2, Yin Nian 1,2, Lin Zhou 1, Hongjie Zhang 3 and Minghua Qiu 1,2,* 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming, 650204, P. R. China 2 Graduate School of the Chinese Academy of Sciences, Beijing, 100039, P. R. China 3 Program for Collaborative Research in the Pharmaceutical Sciences, (m/c877), Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, the University of Illinois at Chicago, 833 S. Wood St., Chicago, IL 60612, USA * Author to whom correspondence should be addressed; E-mail: mhchiu@; Fax: (+86)-871-5223255. Received: 17 May 2008; in revised form: 17 July 2008 / Accepted: 18 July 2008 / Published: 13 August 2008 Abstract: Five new 9,19-cycloartane triterpene diglycosides, which have been named cimiaceroside C (1), and cimifosides A-D (2-5) together with the known compounds cimiracemoside D (6), cimidahurine (7) and α-D-glucopyranosyl-l-β-D-fructofuranoside (8) were isolated from the rhizome of Cimicifuga foetida. The new triterpene diglycosides 1-5 were identified as cimiacerol-3-O-β-D-xylopyranosyl-(1→3)-β-D-xylopyranoside, 12β-hydroxycimigenol-3-O-β-D-xylopyranosyl-(1→3)-β-D-xylopyranoside, 25-O- acetylc