n-terminally myristoylated feline foamy virus gag allows env-independent budding of sub-viral particles氨基端myristoylated猫泡沫病毒gag允许env-independent崭露头角的亚病毒颗粒.pdfVIP

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n-terminally myristoylated feline foamy virus gag allows env-independent budding of sub-viral particles氨基端myristoylated猫泡沫病毒gag允许env-independent崭露头角的亚病毒颗粒.pdf

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n-terminally myristoylated feline foamy virus gag allows env-independent budding of sub-viral particles氨基端myristoylated猫泡沫病毒gag允许env-independent崭露头角的亚病毒颗粒

Viruses 2011, 3, 2223-2237; doi: 10.3390/v3112223 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Article N-Terminally Myristoylated Feline Foamy Virus Gag Allows Env-Independent Budding of Sub-Viral Particles Yang Liu, Yong-Boum Kim † and Martin Löchelt * Department of Genome Modifications and Carcinogenesis, Research Program Infection and Cancer, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany; E-Mails: y.liu@dkfz.de (Y.L.); kim@nmr.uni-frankfurt.de (Y.-B.K.) † Current address: Institute for Molecular Biosciences, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max von Laue-Straße 9, 60438 Frankfurt am Main, Germany. * Author to whom correspondence should be addressed; E-Mail: m.loechelt@dkfz.de; Tel.: +49-6621-42-4933; Fax: +49-6621-42-4932. Received: 29 August 2011; in revised form: 4 November 2011 / Accepted: 4 November 2011 / Published: 14 November 2011 Abstract: Foamy viruses (FVs) are distinct retroviruses classified as Spumaretrovirinae in contrast to the other retroviruses, the Orthoretrovirinae. As a unique feature of FVs, Gag is not sufficient for sub-viral particle (SVP) release. In primate and feline FVs (PFV and FFV), particle budding completely depends on the cognate FV Env glycoproteins. It was recently shown that an artificially added N-terminal Gag myristoylation signal (myr-signal) overcomes this restriction in PFV inducing an Orthoretrovirus-like buddi