原创力文档nuclear beta-catenin overexpression in metastatic sentinel lymph node is associated with synchronous liver metastasis in colorectal cancer核β-连环蛋白过度转移前哨淋巴结与同步在结直肠癌肝转移相关.pdfVIP
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nuclear beta-catenin overexpression in metastatic sentinel lymph node is associated with synchronous liver metastasis in colorectal cancer核β-连环蛋白过度转移前哨淋巴结与同步在结直肠癌肝转移相关
Cheng et al. Diagnostic Pathology 2011, 6:109
/content/6/1/109
RESEARCH Open Access
Nuclear beta-catenin overexpression in metastatic
sentinel lymph node is associated with
synchronous liver metastasis in colorectal cancer
1* 2 1 1
Hongxia Cheng , Hui Liang , Yejun Qin and Ying Liu
Abstract
Background: Beta-catenin, a component of the Wingless/Wnt signaling pathway, can activate target genes linking
with the adenomatous polyposis coli (APC) gene in colorectal cancer. The purpose of this study is to investigate
whether nuclear beta-catenin overexpression in metastatic sentinel lymph node(s) [SLN(s)] is associated with
synchronous liver metastasis.
Methods: Clinicopathological data from 355 patients (93 cases with liver metastasis and 262 cases without liver
metastasis) were reviewed. Beta-catenin expression in metastatic SLN(s) and liver metastatic lesions was examined
by immunohistochemistry. The association of nuclear beta-catenin expression in metastatic SLN(s) and liver
metastatic lesions was evaluated, and the relationship between nuclear beta-catenin expression and
clinicopathological characteristics was analyzed. Finally, univariate and logistic multivariate regression analyses were
adopted to discriminate the risk factors of liver metastasis.
Results: Nuclear beta-catenin overexpression in metastatic SLN(s) was observed in 70 patients with liver metastasis
and 31 patients without liver metastasis (75.3% vs. 11.8%; P 0.001). Nuclear beta-catenin expression was noted in
all the metastatic lesions. Spearman rank correlation analysis demonstrated that nuclear beta-catenin expression in
metastatic SLN(s) had a positive correlation with that in metastatic lesions (r = 0.425, P 0.001). Univariate and
multivariate analyses in
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