non steroidal anti-inflammatory drugs and inflammatory bowel disease非甾类抗炎药和炎症性肠病.pdfVIP

Pharmaceuticals 2010, 3, 1084-1092; doi:10.3390/ph3041084 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review Non Steroidal Anti-Inflammatory Drugs and Inflammatory Bowel Disease Amir Klein and Rami Eliakim * Department of Gastroenterology, Rambam Health Care Campus, Haifa, P.O.B. 9602, Haifa, 31096, Israel * Author to whom correspondence should be addressed; E-Mail: r_eliakim@.il; Tel.: +97-248-543-784; Fax: +97-248-543-058. Received: 13 January 2010; in revised form: 1 April 2010/ Accepted: 9 April 2010 / Published: 12 April 2010 Abstract: Inflammatory Bowel Diseases (IBD) are an immune mediated chronic or relapsing disorders of the gastrointestinal (GI) tract. IBD is characterized by a chronic intestinal inflammatory process with various components contributing to the pathogenesis of the disease including environmental factors such as smoking or use of Non Steroidal Anti-Inflammatory Drugs (NSAIDS). NSAIDS are among the most commonly used medications for the treatment of various inflammatory conditions. The main factor limiting NSAIDS use is the concern for the development of gastrointestinal toxicity including mucosal injury. A possible association between the use of NSAIDS and the onset or relapse of IBD has been repeatedly suggested. This article will review the current concepts and evidence of the relationship between IBD and NSAIDS. Keywords: NSAIDs;