non-additive effects of rbp4, esr1 and igf2 polymorphisms on litter size at different parities in a chinese-european porcine line非附加的影响rbp4,esr1 igf2多态性在垃圾大小不同的平价chinese-european猪.pdfVIP

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non-additive effects of rbp4, esr1 and igf2 polymorphisms on litter size at different parities in a chinese-european porcine line非附加的影响rbp4,esr1 igf2多态性在垃圾大小不同的平价chinese-european猪.pdf

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non-additive effects of rbp4, esr1 and igf2 polymorphisms on litter size at different parities in a chinese-european porcine line非附加的影响rbp4,esr1 igf2多态性在垃圾大小不同的平价chinese-european猪

Muñoz et al. Genetics Selection Evolution 2010, 42:23 Ge n e t i c s /content/42/1/23 Se l e c t i o n Evolution R E S E A R C H Open Access Research Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line María Muñoz*, Ana Isabel Fernández, Cristina Óvilo, Gloria Muñoz, Carmen Rodriguez, Almudena Fernández, Estefânia Alves and Luis Silió Abstract Background: The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Moreover, we investigated a possible effect of the interaction between RBP4-Msp I and ESR1-PvuII polymorphisms. The IGF2-intron3-G3072A polymorphism is actually used to select lean growth, but other possible effects of this polymorphism on reproductive traits need to be evaluated. Methods: Detection of polymorphisms in the genomic and cDNA sequences of RBP4 gene was carried out. RBP4-Msp I and IGF2-intron3-G3072A were genotyped in a hyperprolific Chinese-European line (Tai-Zumu) and three new RBP4 polymorphisms were genotyped in different pig breeds. A bivariate animal model was implemented in association analyses considering the number of piglets born alive at early (NBA12) and later parities (NBA3+ ) as different traits. A joint analysis of RBP4-Msp I and ESR1-PvuII was performed to test their possible interaction. In the IGF2 analysis, paternal or maternal imprinting effects were also considered. Result