network strategies to understand the aging process and help age-related drug design网络策略了解衰老过程,帮助与年龄相关的药物设计.pdfVIP

Review Network strategies to understand the aging process and help age-related drug design Gábor I Simkó, Dávid Gyurkó, Dániel V Veres, Tibor Nánási and Peter Csermely Address: Semmelweis University, Department of Medical Chemistry, PO Box 260, H­1444 Budapest, Hungary. Correspondence: Peter Csermely. E­mail: csermely@eok.sote.hu • the reliability theory gives a rather descriptive picture of Abstract aging, emphasizing that aging is a phenomenon of Recent studies have demonstrated that network approaches are highly appropriate tools for understanding the extreme complex­ increasing risk of failure with the passage of time ity of the aging process. Moreover, the generality of the network • the network theory of aging integrates many elements of concept helps to define and study the aging of technological and the previous theories and describes the shifting balance social networks and ecosystems, which may generate novel between various types of damage and repair mechanisms concepts for curing age­related diseases. The current review during aging of cellular systems. The young state is focuses on the role of protein­protein interaction networks (inter­ characterized by well­repaired damage, while the aged actomes) in aging. Hubs and inter­modular elements of both interactomes and signaling networks are key regulators of the organism cannot cope with the accumulated damage, aging process. Aging induces an increase in the permeability of and gradually surrenders [1­6]. several cellular c