numerical techniques for the analysis of polygenes sampled from natural populations数值分析技术的多基因样本从自然种群.pdfVIP

Numerical techniques for the analysis of polygenes sampled from natural populations J.N. THOMPSON, jr. Jenna J. HELLACK G.D. SCHNELL * Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, U.S.A. ** Department of Biology, Central State University, Edmond, Oklahoma 73034, U.S.A. Summary While polygenic factors contribute to almost every aspect of development, the small quantitative contributions of individual polygenic loci are typically difficult to analyze. A number of studies under controlled laboratory environments have shown that a large proportion of the variation in a quantitative trait can often be traced to a relatively small number of segregating loci. In natural populations, the establishment of a series of isofemale strains provides a sample of the segregating genetic variation. Furthermore, in each strain, the segregating genetic component is dramatically simplified. In this paper we describe numerical techniques than can be used to summarize interstrain differences based upon detected patterns of genetic segregation in isofemale lines. These techniques include UPGMA cluster analysis, K-group cluster analysis, and principal coordinates analysis. Distances between phenotypic distributions of isofemale line progeny are provided by the Kolmogorov-Smirnov (K-S) two-sample test. Overall, the use of K-S distances in conjunction with clustering and ordination techniques shows great promise in assisting population geneticists in the identification of strains with similar genetic characteristics. Key words : Quantitative variation, simulation, cluster analysis, Drosophila melanogaster.