原创力文档noninvasive biomarkers for the diagnosis of steatohepatitis and advanced fibrosis in nafld肝病的无创性诊断生物标记和先进的肝纤维化的非酒精性脂肪肝.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
noninvasive biomarkers for the diagnosis of steatohepatitis and advanced fibrosis in nafld肝病的无创性诊断生物标记和先进的肝纤维化的非酒精性脂肪肝
Pearce et al. Biomarker Research 2013, 1:7
/content/1/1/7
REVIEW Open Access
Noninvasive biomarkers for the diagnosis of
steatohepatitis and advanced fibrosis in NAFLD
† † *
Steven G Pearce , Nirav C Thosani and Jen-Jung Pan
Abstract
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of abnormal liver enzymes in both adults and
children. NAFLD has a histologic spectrum ranging from simple steatosis to nonalcoholic steatohepatitis (NASH),
advanced fibrosis, and cirrhosis. It is imperative to distinguish simple steatosis from NASH since the latter has a
progressive disease course and can lead to end-stage liver disease. Liver biopsy has been considered as the gold
standard for the diagnosis of NASH. However, liver biopsy is invasive, costly, and can rarely cause significant
morbidity (risk of morbidity, 0.06-0.35%; risk of mortality, 0.1-0.01%). Imaging studies such as ultrasonography,
computed tomography, and magnetic resonance imaging have limited sensitivity in detecting steatosis and cannot
distinguish steatosis from NASH. Alanine aminotransferase (ALT) has been used as a surrogate marker for liver
injuries. However, ALT is not an ideal marker for either diagnosis of NAFLD or distinguishing steatosis from NASH.
Better noninvasive biomarkers or panels of biomarkers that are cheaper, reliable, and reproducible are urgently
needed for patients with NASH to assist in establishing diagnosis, providing risk information, and monitoring
disease progression and treatment response. In this article, we plan to concisely review the current advances in the
use of biomarkers for the diagnosis of NASH.
Keyword: Biomarker, Noninvasive, NAFLD, NASH, Fibrosis
Introduction
您可能关注的文档
- neurodevelopmental outcome related to cerebral risk factors in children after neonatal arterial switch operation儿童神经发育的结果与脑相关风险因素后,新生儿动脉开关操作.pdf
- neurofeedback and biofeedback with 37 migraineurs a clinical outcome studyneurofeedback和生物反馈37偏头痛患者临床结果的研究.pdf
- neurological complications after cardiac surgery in adults在成人心脏手术后神经系统并发症.pdf
- neurological soft signs in persons with amnestic mild cognitive impairment and the relationships to neuropsychological functions神经系统软体征人遗忘轻度认知障碍和神经心理功能的关系.pdf
- neurological disease rises from ocean to bring model for human epilepsy to life神经系统疾病从海洋带来人类癫痫模型.pdf
- neuroimmune perspectives in sepsis神经免疫角度在脓毒症.pdf
- neuromuscular blockers and ards thou shalt not breathe, move, or die!神经肌肉阻滞剂和ards不可呼吸,运动,或死亡!.pdf
- neuromuscular deterioration in the early stage of sepsis in rats神经肌肉恶化脓毒症大鼠的早期阶段.pdf
- neuromems neural probe microtechnologiesneuromems神经探针技术.pdf
- neuromorphic vlsi models of selective attention from single chip vision sensors to multi-chip systems神经形态vlsi的选择性注意模型从单片multi-chip系统的视觉传感器.pdf
- non-intrusive load monitoring approaches for disaggregated energy sensing a survey非侵入性的负载监测方法分解能量传感测量.pdf
- noninvasive method to estimate anaerobic threshold in individuals with type 2 diabetes非侵入性方法来估计无氧阈值在2型糖尿病患者.pdf
- noninvasive positive pressure ventilation for respiratory failure caused by exacerbations of chronic obstructive pulmonary disease a standard of care无创正压通气对呼吸衰竭引起的急性加重的慢性阻塞性肺疾病的标准治疗.pdf
- non-invasive mr imaging of inflammation in a patient with both asymptomatic carotid atheroma and an abdominal aortic aneurysm a case report非侵入性成像先生的炎症患者无症状的颈动脉粥样硬化和腹主动脉瘤病例报告.pdf
- noninvasive mechanical ventilation may be useful in treating patients who fail weaning from invasive mechanical ventilation a randomized clinical trial无创机械通气治疗失败的患者可能有用断奶侵入性机械通气随机临床试验.pdf
- non-invasive stroke volume measurement and passive leg raising predict volume responsiveness in medical icu patients an observational cohort study非侵入性中风体积测量和被动腿提高预测体积响应在医学icu病人一项观察性队列研究.pdf
- non-invasive optical biosensor for probing cell signaling非侵入性的光学生物传感器探测细胞信号.pdf
- noninvasive positive pressure ventilation for acute respiratory failure in children a concise review无创正压通气对急性呼吸衰竭儿童一个简洁的审查.pdf
- non-contact plant growth measurement method and system based on ubiquitous sensor network technologies非接触式植物生长测量方法和系统基于泛在传感器网络技术.pdf
- nonlinear adaptive pid control for greenhouse environment based on rbf network非线性自适应pid控制温室环境基于rbf网络.pdf
文档评论（0）