原创力文档neurological soft signs in persons with amnestic mild cognitive impairment and the relationships to neuropsychological functions神经系统软体征人遗忘轻度认知障碍和神经心理功能的关系.pdfVIP
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neurological soft signs in persons with amnestic mild cognitive impairment and the relationships to neuropsychological functions神经系统软体征人遗忘轻度认知障碍和神经心理功能的关系
Li et al. Behavioral and Brain Functions 2012, 8:29
/content/8/1/29
RESEARCH Open Access
Neurological soft signs in persons with amnestic
mild cognitive impairment and the relationships
to neuropsychological functions
1 1,2 3 4 5 1*
Hui-jie Li , Peng-yun Wang , Yang Jiang , Raymond C K Chan , Hua-li Wang and Juan Li
Abstract
Background: Neurological abnormalities have been reported in people with amnestic mild cognitive impairment
(aMCI). The current study aimed to examine the prevalence of neurological soft signs (NSS) in this clinical group
and to examine the relationship of NSS to other neuropsychological performances.
Methods: Twenty-nine people with aMCI and 28 cognitively healthy elderly people were recruited for the present
study. The NSS subscales (motor coordination, sensory integration, and disinhibition) of the Cambridge Neurological
Inventory and a set of neuropsychological tests were administered to all the participants.
Results: People with aMCI exhibited significantly more motor coordination signs, disinhibition signs, and total NSS
than normal controls. Correlation analysis showed that the motor coordination subscale score and total score of
NSS were significantly inversely correlated with the combined Z-score of neuropsychological tests in aMCI group.
Conclusions: These preliminary findings suggested that people with aMCI demonstrated a higher prevalence of
NSS compared to healthy elderly people. Moreover, NSS was found to be inversely correlated with the
neuropsychological performances in persons with aMCI. When taken together, these findings suggested that NSS
may play a potential important role and serve as a tool to assist in the early detection of aMCI.
Key
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