原创力文档ocular lesions in 1,000 consecutive hiv-positive patients in india a long-term study眼部病变连续1000年艾滋病毒阳性患者在印度一项长期研究.pdfVIP
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ocular lesions in 1,000 consecutive hiv-positive patients in india a long-term study眼部病变连续1000年艾滋病毒阳性患者在印度一项长期研究
Sudharshan et al. Journal of Opthalmic Inflammation and Infection 2013, 3:2
/content/3/1/2
ORIGINAL RESEARCH Open Access
Ocular lesions in 1,000 consecutive HIV-positive
patients in India: a long-term study
1* 1 1 1 1
Sridharan Sudharshan , Sheikh Kaleemunnisha , Akbar Ashraf Banu , Sankaran Shrikrishna , Amala E George ,
1 2 2 1
B Rajesh Babu , Bella Devaleenal , Nagalingeshwaran Kumarasamy and Jyotirmay Biswas
Abstract
Background: Ocular lesions in patients on highly active antiretroviral therapy (HAART) have shown changes in
disease prevalence and pattern. Although they have been described in the Western population, there are not many
such studies in the HAART era from India. This study aims to present the clinical profile, systemic correlation, and
visual outcome in HIV-positive patients in relation to HAART in comparison with pre-HAART Indian studies and
current Western data. Ocular findings and systemic correlation in 1,000 consecutive patients with HIV seen at a
tertiary eye care center were analyzed. This study uses a prospective observational case series design.
Results: Age range of the patients was 1.5 to 75 years. Ocular lesions were seen in 68.5% of the patients
(cytomegalovirus (CMV) retinitis was the commonest). The commonest systemic disease was pulmonary TB. Mean
interval between HIV diagnosis and onset of ocular lesions was 2.43 years. CD4 counts range from 2 to 1,110 cells/
mm3. Immune recovery uveitis (IRU) was seen in 17.4%. Interval between HAART initiation and IRU was 4 months to
2.5 years. Recurrence of ocular infection was seen in 2.53% (po
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