原创力文档ocular fundus manifestation of two patients following long-term chloroquine therapy a case report眼的眼底表现两个病人长期氯喹治疗病例报告.pdfVIP
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ocular fundus manifestation of two patients following long-term chloroquine therapy a case report眼的眼底表现两个病人长期氯喹治疗病例报告
Ma et al. Diagnostic Pathology 2010, 5:20
/content/5/1/20
CASE REPORT Open Access
Ocular fundus manifestation of two patients
following long-term chloroquine therapy: a case
report
1* 2 1 3 2
Xiaoyun Ma , Liang Yan , Linping He , Dongyi He , Hao Lu
Abstract
This report describes the typical manifestations of chloroquine retinopathy with some advanced new technology. A
series of examinations were performed on the patients, including the fundus fluorescein angiography, optical
coherence tomography, GDxVCC Nerve Fiber Analyzer, full-field electroretinography, multifocal electroretinography
and visual field examinations, to provide a better understanding of chloroquine retinopathy.
Introduction total dose of approximately 800 g of the drug (250 mg
Chloroquine has long been used in the treatment and daily for two years, then 250 mg alternative daily for 14
prevention of malaria[1-4], and for a long time, the agent years). Her visual acuity had decreased gradually during
is still being used to treat other diseases. For example, the previous 5 years. At her latest examination, her
due to its immunosuppressive effects, chloroquine has visual acuity was 20/100 OD and hand motions OS,
been used in the treatment of autoimmune disorders, Goldmann applanation intraocular pressure was normal
such as rheumatoid arthritis and lupus erythematosus. (OD16 mmHg, OS 16 mmHg), but the center visual
Chloroquine has also been tested in clinical trials as an field (10-2 Humphrey Visual Field Analyzer, Humphrey
antiretroviral agent against HIV [5] and as a radiosensiti- Instruments I
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