novel biochip platform for nucleic acid analysis新型生物芯片核酸分析的平台.pdfVIP

Sensors 2012, 12, 8100-8111; doi:10.3390/s120608100 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Article Novel Biochip Platform for Nucleic Acid Analysis 1,† 2, ,† 1 2 Salvatore Pernagallo , Giorgio Ventimiglia * , Claudia Cavalluzzo , Enrico Alessi , Hugh Ilyine 1, Mark Bradley 3 and Juan J. Diaz-Mochon 1,* 1 DestiNA Genomics Ltd., West Mains Road, Edinburgh EH9 3JJ, UK; E-Mails: salvatore.pernagallo@ (S.P.); claudia@ (C.C.); hugh@ (H.I.) 2 STMicroelectronics, ANALOG, MEMS and SENSORS Group, Healthcare BDU, Stradale Primosole 50, Catania 95121, Italy; E-Mail: enrico.alessi@ 3 School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK; E-Mail: mark.bradley@ed.ac.uk † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: giorgio.ventimiglia@ (G.V.); juan@ (J.J.D.-M.); Tel.: +39-095-740-4344 (G.V.); +44-0-131-650-4821 (J.J.D.-M.). Received: 25 April 2012; in revised form: 21 May 2012 / Accepted: 31 May 2012 / Published: 11 June 2012 Abstract: This manuscript describes the use of a novel biochip platform for the rapid analysis/identification of nucleic acids, including DNA and microRNAs, with very high specificity. This approach combines a unique dynamic chemistry approach for nucleic acid testing and analysis developed by DestiNA Genomics with the STMicroelectronics