novel coumarin derivatives containing 1,2,4-triazole, 4,5-dicyanoimidazole and purine moieties synthesis and evaluation of their cytostatic activity新型香豆素衍生物包含1、2、4-triazole 4 5-dicyanoimidazole嘌呤合成和评估他们的半个抑制细胞生长的活动.pdfVIP

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novel coumarin derivatives containing 1,2,4-triazole, 4,5-dicyanoimidazole and purine moieties synthesis and evaluation of their cytostatic activity新型香豆素衍生物包含1、2、4-triazole 4 5-dicyanoimidazole嘌呤合成和评估他们的半个抑制细胞生长的活动.pdf

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novel coumarin derivatives containing 1,2,4-triazole, 4,5-dicyanoimidazole and purine moieties synthesis and evaluation of their cytostatic activity新型香豆素衍生物包含1、2、4-triazole 4 5-dicyanoimidazole嘌呤合成和评估他们的半个抑制细胞生长的活动

Molecules 2012, 17, 11010-11025; doi:10.3390/molecules170911010 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Novel Coumarin Derivatives Containing 1,2,4-Triazole, 4,5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity 1 1 1 2 2 Krešimir Benci , Leo Mandić , Tomislav Suhina , Mirela Sedić , Marko Klobučar , Sandra Kraljević Pavelić2 2 1 1, , Krešimir Pavelić , Karlo Wittine and Mladen Mintas * 1 Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, Zagreb 10000, Croatia 2 Department of Biotechnology, University of Rijeka, Slavka Krautzeka 83 A, Rijeka 51000, Croatia * Author to whom correspondence should be addressed; E-Mail: mladen.mintas@fkit.hr; Tel.: +385-1-4597-214; Fax: +385-1-4597-250. Received: 16 July 2012; in revised form: 23 August 2012 / Accepted: 3 September 2012 / Published: 12 September 2012 Abstract: We report here on the synthesis and in vitro anti-tumor effects of a series of novel 1,2,4-triazole (compounds 3–6), 4,5-dicyanoimidazole (compound 7), and purine (compounds 8–13) coumarin derivatives and their acyclic nucleoside analogues 14–18. Structures of novel compounds 3–18 were deduced from their 1H- an