原创力文档novel multi-targeted polymerase chain reaction for diagnosis of presumed tubercular uveitis新型多靶向聚合酶链反应对假定结节的葡萄膜炎的诊断.pdfVIP
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novel multi-targeted polymerase chain reaction for diagnosis of presumed tubercular uveitis新型多靶向聚合酶链反应对假定结节的葡萄膜炎的诊断
Sharma et al. Journal of Ophthalmic Inflammation and Infection 2013, 3:25
/content/3/1/25
ORIGINAL RESEARCH Open Access
Novel multi-targeted polymerase chain reaction
for diagnosis of presumed tubercular uveitis
1 2 2 3 1 2*
Kusum Sharma , Vishali Gupta , Reema Bansal , Aman Sharma , Meera Sharma and Amod Gupta
Abstract
Background: The objective of this study was to report the use of multi-targeted polymerase chain reaction (PCR) in
the diagnosis of presumed tubercular uveitis. Multi-targeted PCR using three targets specific for Mycobacterium
tuberculosis, i.e., IS6110, MPB64, and protein b, was performed on intraocular fluid samples of 25 subjects. Nine had
presumed tubercular uveitis, six had intraocular inflammation secondary to a nontubercular etiology (disease
controls), and ten had no evidence of intraocular inflammation (normal controls). As described previously, response
to antitubercular therapy was considered as the gold standard.
Results: Multi-targeted PCR was positive in seven out of nine patients with presumed tubercular uveitis and
negative in all normal and disease controls. The sensitivity and specificity were 77.77% and 100%, respectively. For
the diagnosis of presumed tubercular uveitis, multi-targeted PCR had a positive predictive value of 100% and a
negative predictive value of 88.88%.
Conclusion: Multi-targeted PCR can be a valuable tool for diagnosing presumed tubercular uveitis.
Keywords: Uveitis, Tubercular, Polymerase chain reaction, Multi-targeted PCR
Background to antitubercular therapy (ATT) [1,3-7]. One of the reasons
Establishing a definitive diagnosis of presumed tubercu-
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