原创力文档novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery新颖的多态性interleukin-18与更大的心脏手术后的炎症有关.pdfVIP
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novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery新颖的多态性interleukin-18与更大的心脏手术后的炎症有关
Available online /content/13/1/R9
Vol 13 No 1 Open Access
Research
Novel polymorphism of interleukin-18 associated with greater
inflammation after cardiac surgery
David M Shaw, Ainsley M Sutherland, James A Russell, Samuel V Lichtenstein and Keith R Walley
Critical Care Research Laboratories, Heart + Lung Institute, University of British Columbia, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
Corresponding author: Keith R Walley, kwalley@mrl.ubc.ca
Received: 3 Sep 2008 Revisions requested: 28 Oct 2008 Revisions received: 1 Dec 2008 Accepted: 29 Jan 2009 Published: 29 Jan 2009
Critical Care 2009, 13:R9 (doi:10.1186/cc7698)
This article is online at: /content/13/1/R9
© 2009 Shaw et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Interleukin (IL)-18 is a key modulator of the stay (6.8% for TT genotype versus 2.7% for GG or GT
cytokine response that leads to organ dysfunction and genotype; p = 0.015). Patients homozygous for the T allele also
prolonged intensive care unit (ICU) stay after cardiopulmonary had increased occurrence of low systemic vascular resistance
bypass surgery. We hypothesised that variation in the pro- index (62%) compared with the GG and GT genotypes (53%;
inflammatory gene IL-18 is associated with adverse clinical p = 0.045). Patients homozygous for the T allele had increased
outcome because of a more intense inflammator
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