原创力文档novel strategies to improve the anticancer action of 5-fluorouracil by using drug delivery systems新策略来提高5 -氟尿嘧啶的抗癌作用通过使用药物输送系统.pdfVIP
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novel strategies to improve the anticancer action of 5-fluorouracil by using drug delivery systems新策略来提高5 -氟尿嘧啶的抗癌作用通过使用药物输送系统
Molecules 2008, 13, 2340-2369; DOI: 10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/molecules
Review
Novel Strategies to Improve the Anticancer Action of
5-Fluorouracil by Using Drug Delivery Systems
José L. Arias
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of
Granada, Campus Universitario de Cartuja s/n, 18071 Granada, Spain; E-mail: jlarias@ugr.es;
Tel.: (+34) 958 24 39 00; Fax: (+34) 958 24 89 58
Received: 22 August 2008; in revised form: 16 September 2008 / Accepted: 16 September 2008 /
Published: 1 October 2008
Abstract: Because of the fundamental importance of new therapeutic routes for cancer
treatment, a number of systems based on colloidal particles as vehicles for the delivery of
the anticancer drug 5-fluorouracil have been devised. The target is always to provide the
proper dose of the antitumor agent only at the desired locus of action, thus reducing the
unwanted side effects. In this review, the main strategies and the more significant results in
the development of 5-fluorouracil carriers for cancer treatment are discussed.
Keywords: Biodegradable polymers; Cancer treatment; Drug carriers; 5-Fluorouracil;
Vesicular systems
1. Introduction
Apart from surgery, radiation and biologic therapies (immunotherapy and hormonal therapy), the
therapeutic strategies presently used in the clinical practice for cancer treatment are focused on
cytotoxic drugs as the main form of chemotherapy for cancer. Cytotoxic d
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