原创力文档no association between comt val158met polymorphism and suicidal behavior meta-analysis and new data之间没有联系comt val158met多态性和自杀行为分析和新数据.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
no association between comt val158met polymorphism and suicidal behavior meta-analysis and new data之间没有联系comt val158met多态性和自杀行为分析和新数据
Tovilla-Zárate et al. BMC Psychiatry 2011, 11:151
/1471-244X/11/151
RESEARCH ARTICLE Open Access
No association between COMT val158met
polymorphism and suicidal behavior: meta-
analysis and new data
1* 2 1 3 4
Carlos Tovilla-Zárate , Isela Juárez-Rojop , Teresa Ramón-Frias , Mario Villar-Soto , Sherezada Pool-García ,
5 6 7 6
Beatriz Camarena Medellín , Alma D Genis Mendoza , Lilia López Narvaez and Nicolini Humberto
Abstract
Background: The polymorphism COMTval158met has been associated with suicidal behavior in case-control and
meta-analysis studies, but results and conclusions remain controversial. The objective of this study was to examine
the association between COMT val158met with suicidal behavior in a case-control study and to assess the
combined evidence -this case-control study and available data from other related studies- we carried out a meta-
analysis.
Methods: We conducted a case-control study with 105 patients with suicide attempts and 236 controls.
Subsequently, we performed a meta-analysis of published genetic association studies by searching through
Medline, PubMed and Web of Science databases.
Results: No significant differences were found in the distribution of alleles (c2 = 0.33, 1 df, p = 0.56) or genotypes
(c2 = 2.36, 2 df, p = 0.26). The meta-analysis comprising 12 association studies (including the present one) showed
that the risk COMTmet allele of COMTval158/met is not associated with suicidal behavior (OR: 1.09, 95% CI: 0.97-
1.23), even in the absence of heterogeneity (OR: 1.09, 95% CI: 0.97-1.23).
Conclusion: Our results
您可能关注的文档
- need and methods of gene conservation in animal breeding需要在动物育种和基因保护的方法.pdf
- negative regulation of cytokine signaling and immune responses by socs proteins负调节细胞因子信号和soc免疫反应的蛋白质.pdf
- negative selection pressure against premature protein truncation is reduced by both alternative splicing and diploidy负选择压力反对过早蛋白质截断减少可变剪接和二倍性.pdf
- negative-pressure cavitation extraction of four main vinca alkaloids from catharanthus roseus leaves负压空化四个主要的提取长春花生物碱从catharanthus roseus也叫叶子.pdf
- neglschisandrins a-b two new dibenzocyclooctene lignans from schisandra neglecta从五味子neglecta neglschisandrins a - b两个新的dibenzocyclooctene木酚素.pdf
- nef-specific cd45ra+ cd8+ t cells secreting mip-1β but not ifn-γ are associated with nonprogressive hiv-1 infectionnef-specific cd45ra + cd8 + t细胞分泌mip-1β但不是ifn-γ与nonprogressive hiv - 1感染.pdf
- neglschisandrins c-d two new dibenzocyclooctadiene lignans from schisandra neglecta从五味子neglecta neglschisandrins c - d两个新的dibenzocyclooctadiene木酚素.pdf
- neighbors like me religious affiliation and neighborhood racial preferences among non-hispanic whites邻居喜欢我宗教信仰和社区种族偏好的非西班牙裔白人.pdf
- neighborhood consistency in mental arithmetic behavioral and erp evidence社区的一致性心算行为和erp的证据.pdf
- neglected canals deterioration of indigenous irrigation system by urbanization in the west peri-urban area of bangkok metropolitan region被忽视的运河恶化本土灌溉系统的城市化在西方曼谷大都会地区的城市周边地区.pdf
- nmr-based metabolomic investigations on the differential responses in adductor muscles from two pedigrees of manila clam ruditapes philippinarum to cadmium and zincnmr-based代谢组学研究微分响应的内收肌的肌肉从两个谱系马尼拉蛤菲律宾蛤仔的镉和锌.pdf
- nmr studies and molecular dynamic simulation of synthetic dendritic antigens核磁共振研究和分子动态模拟合成树枝状的抗原.pdf
- nitrogen doped carbon nanotubes from organometallic compounds a review氮掺杂碳纳米管的有机金属化合物进行审查.pdf
- no evidence for an association between the -871 tc promoter polymorphism in the b-cell-activating factor gene and primary sj？gren's syndrome没有证据表明之间的一个关联-871 tc b-cell-activating因子基因的启动子多态性和初级sj gren综合征.pdf
- no differences in cardiovascular autonomic responses to mental stress in chronic fatigue syndrome adolescents as compared to healthy controls没有不同的心血管自主神经反应在慢性疲劳综合症青少年精神压力与健康对照组相比.pdf
- no evidence of horizontal infection in horses kept in close contact with dogs experimentally infected with canine influenza a virus (h3n8)没有证据表明水平感染马保持密切接触狗实验感染犬流感病毒(h3n8).pdf
- no evidence for uv-based nest-site selection in sticklebacks没有证据uv-based巢穴地点选择在刺鱼.pdf
- no effect of omeprazole on ph of exhaled breath condensate in cough associated with gastro-oesophageal reflux没有呼出气息的奥美拉唑对ph值的影响在咳嗽与gastro-oesophageal回流冷凝.pdf
- nmr-metabolic methodology in the study of gm foodsnmr-metabolic方法论研究的转基因食品.pdf
- no effect of mate novelty on sexual motivation in the freshwater snail biomphalaria glabrata没有影响伴侣新奇性动机的淡水蜗牛biomphalaria glabrata.pdf
文档评论（0）