原创力文档nsaids in the acute treatment of migraine a review of clinical and experimental data非甾体抗炎药在急性治疗偏头痛的临床和实验数据.pdfVIP
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nsaids in the acute treatment of migraine a review of clinical and experimental data非甾体抗炎药在急性治疗偏头痛的临床和实验数据
Pharmaceuticals 2010, 3, 1966-1987; doi:10.3390/ph3061966
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
NSAIDs in the Acute Treatment of Migraine: A Review of
Clinical and Experimental Data
Arpad Pardutz 1 and Jean Schoenen 2,*
1 Department of Neurology, University of Szeged, Semmelweis u. 6. Szeged, Hungary H-6720,
Hungary; E-Mail: apardutz@ (A.P.)
2 Headache Research Unit, Department of Neurology GIGA Neurosciences, Liège University,
CHU-Sart Tilman, T4(+1), B36, B-4000 Liège, Belgium
* Author to whom correspondence should be addressed; E-Mail: jschoenen@ulg.ac.be ;
Tel: +32(0 Fax: +32(0
Received: 27 April 2010; in revised form: 18 May 2010 / Accepted: 11 June 2010 /
Published: 17 June 2010
Abstract: Migraine is a common disabling neurological disorder with a serious socio-
economical burden. By blocking cyclooxygenase nonsteroidal anti-inflammatory drugs
(NSAIDs) decrease the synthesis of prostaglandins, which are involved in the
pathophysiology of migraine headaches. Despite the introduction more than a decade ago
of a new class of migraine-specific drugs with superior efficacy, the triptans, NSAIDs
remain the most commonly used therapies for the migraine attack. This is in part due to
their wide availability as over-the-counter drugs and their pharmaco-economic advantages,
but also to a favorable efficacy/side effect profile at least in attacks of mild and moderate
intensity. We summarize he
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