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nsaids and acute pancreatitis a systematic review非甾体抗炎药和急性胰腺炎系统回顾
Pharmaceuticals 2010, 3, 558-571; doi:10.3390/ph3030558
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
NSAIDs and Acute Pancreatitis: A Systematic Review
Raffaele Pezzilli *, Antonio Maria Morselli-Labate and Roberto Corinaldesi
Department of Digestive Diseases and Internal Medicine, Sant’Orsola-Malpighi Hospital, Via
Massarenti 9, 40138 Bologna, Italy; E-Mails: antonio.morselli@unibo.it (A.M.M.-L.);
roberto.corinaldesi@unibo.it (R.C.)
* Author to whom correspondence should be addressed; E-Mail: raffaele.pezzilli@aosp.bo.it;
Tel.: +39-051-636-4148; Fax: +39-051-636-4148.
Received: 2 January 2010; in revised form: 11 February 2010 / Accepted: 9 March 2010 /
Published: 10 March 2010
Abstract: The resulting pain is the main symptom of acute pancreatitis and it should be
alleviated as soon as possible. NSAIDs are the first line therapy for pain and they
are generally administered to acute pancreatitis patients upon admission to the
hospital. In addition, these drugs have also been used to prevent post-endoscopic
cholangiopancreatography (ERCP) acute pancreatitis. On the other hand, there are several
reports indicating that NSAIDs may be the actual cause of acute pancreatitis. We carried
out a literature search on PubMed/MEDLINE; all full text papers published in from
January 1966 to November 2009 on the use of NSAIDs in acute pancreatitis were
collected; the literature search was also supplemented by a review
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