原创力文档nitrogen-containing apigenin analogs preparation and biological activity氮含量芹黄素类似物准备和生物活性.pdfVIP
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nitrogen-containing apigenin analogs preparation and biological activity氮含量芹黄素类似物准备和生物活性
Molecules 2012, 17, 14748-14764; doi:10.3390/molecules171214748
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Nitrogen-Containing Apigenin Analogs:
Preparation and Biological Activity
Rui Liu 1,2, Bin Zhao 1, Dong-En Wang 1, Tianyu Yao 1, Long Pang 1, Qin Tu 1,
Saeed Mahmoud Ahmed 1, Jian-Jun Liu 1,* and Jinyi Wang 1,*
1 Colleges of Science and Forestry, Northwest AF University, Yangling 712100, Shaanxi, China
2 College of Agronomy and Life Sciences, Shanxi Datong University, Datong 037009, Shanxi, China
* Authors to whom correspondence should be addressed; E-Mails: ljj@ (J.-J.L.);
jywang@ (J.W.); Tel./Fax: +86-29-8708-2520 (J.W.).
Received: 30 October 2012; in revised form: 30 November 2012 / Accepted: 5 December 2012 /
Published: 11 December 2012
Abstract: A series of nitrogen-containing apigenin analogs 4a–j was synthesized via
Mannich reactions to develop anticancer, antibacterial, and antioxidant agents from
plant-derived flavonoids. The chemical structures of these compounds were confirmed using
1H-NMR, 13C-NMR, and ESI-MS. The in vitro biological activities of the analogs were
evaluated via assays of their antiproliferative, antibacterial, and antioxidant activities. The
prepared apigenin analogs exhibited different antiproliferative activities against four human
cancer cell lines, namely human cervical (HeLa), human hepatocellular liver (HepG2),
human lung (A549), and human breast (MCF-7) cancer cells. Compound 4i showed the
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