原创力文档nkt-cell lymphoma of bilateral adrenal glands in a patient with pyothoraxnkt双边肾上腺的淋巴瘤患者脓胸.pdfVIP
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nkt-cell lymphoma of bilateral adrenal glands in a patient with pyothoraxnkt双边肾上腺的淋巴瘤患者脓胸
Tsukahara et al. Diagnostic Pathology 2012, 7:114
/content/7/1/114
CASE REPORT Open Access
NK/T-cell lymphoma of bilateral adrenal glands in
a patient with pyothorax
1* 1 1 2 2
Tomohide Tsukahara , Akira Takasawa , Masaki Murata , Kazuyoshi Okumura , Masato Nakayama ,
Noriyuki Sato1 and Tadashi Hasegawa3
Abstract
Primary lymphoma of adrenal glands is rare, and non-B-cell lymphoma associated with pyothorax is also very rare. Here
we report the first autopsy case of non-B-cell lymphoma in bilateral adrenal glands of a 79-year-old woman with
pyothorax who had an aggressive clinical course. Immunohistochemically, tumor cells showed CD3+, CD45RO+, CD5-,
CD7-, CD4-, CD8-, CD10-, CD20-, CD30-, CD79a-, CD138-, CD56-, granzyme B-, TIA-1+ and ALK-. In addition, tumor
cells were strongly EBER1-positive by in situ hybridization. In genomic DNA of tumor cells, T-cell receptor
rearrangements were not detected by southern blotting. We finally diagnosed this case as extranodal NK/T-cell
lymphoma (nasal type).
Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.
eu/vs/8050621197741854.
Keywords: NK/T-cell lymphoma, Adrenal gland, EBV, Pyothorax, Autopsy
Background Case presentation
Lymphoma in the adrenal gland is rare, accounting for A 79-year-old Japanese woman presented with cough and
less than 1% of non-Hodgkin lymphomas. The features of bloody sputum in July 2011. She had been followed since
lymphoma in adrenal glands are: (i) peak age of onset is 1990 by a pulmonologist under the diagnosis of chronic
elderly (mean age of 68 year
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