原创力文档nitrogen dioxide levels estimated from land use regression models several years apart and association with mortality in a large cohort study二氧化氮含量估计从土地利用回归模型分开多年和死亡率在一个大型队列研究协会.pdfVIP
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nitrogen dioxide levels estimated from land use regression models several years apart and association with mortality in a large cohort study二氧化氮含量估计从土地利用回归模型分开多年和死亡率在一个大型队列研究协会
Cesaroni et al. Environmental Health 2012, 11:48
/content/11/1/48
RESEARCH Open Access
Nitrogen dioxide levels estimated from land use
regression models several years apart and
association with mortality in a large cohort study
1* 1 1 1 2 2
Giulia Cesaroni , Daniela Porta , Chiara Badaloni , Massimo Stafoggia , Marloes Eeftens , Kees Meliefste
and Francesco Forastiere1
Abstract
Background: Land Use Regression models (LUR) are useful to estimate the spatial variability of air pollution in
urban areas. Few studies have evaluated the stability of spatial contrasts in outdoor nitrogen dioxide (NO2)
concentration over several years. We aimed to compare measured and estimated NO2 levels 12 years apart, the
stability of the exposure estimates for members of a large cohort study, and the association of the exposure
estimates with natural mortality within the cohort.
Methods: We measured NO2 at 67 locations in Rome in 1995/96 and 78 sites in 2007, over three one-week-long
periods. To develop LUR models, several land-use and traffic variables were used. NO2 concentration at each
residential address was estimated for a cohort of 684,000 adults. We used Cox regression to analyze the association
between the two estimated exposures and mortality.
Results: The mean NO2 measured concentrations were 45.4 μg/m3 (SD 6.9) in 1995/96 and 44.6 μg/m3 (SD 11.0) in
2007, respectively. The correlation of the two measurements was 0.79. The LUR models resulted in adjusted R2 of
0.737 and 0.704, respectively. The correlation of the predicted exposure values for cohort members was 0.96. The
association of each 10 μg/m3 increase in NO2 with mortality was 6 % for 1995/96 and 4 % for 2007 LUR models.
The i
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