nitric oxide in inflammation and pain associated with osteoarthritis一氧化氮与骨关节炎相关的炎症和疼痛.pdfVIP
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nitric oxide in inflammation and pain associated with osteoarthritis一氧化氮与骨关节炎相关的炎症和疼痛
Available online /supplements/10/S2/S2
Review
Nitric oxide in inflammation and pain associated with
osteoarthritis
Steven B Abramson
Division of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, 301 E. 17th Street, New York, NY 10003, USA
Corresponding author: Steven B Abramson, stevenb.abramson@
Published: 17 October 2008 Arthritis Research Therapy 2008, 10(Suppl 2):S2 (doi:10.1186/ar2463)
This article is online at /supplements/10/S2/S2
© 2008 BioMed Central Ltd
Abstract (TNF)-α, and prostaglandins, are all over-produced in
Osteoarthritis (OA) is a degenerative disease involving chondro- chondrocytes harvested from patients with OA (as reviewed
cytes, cartilage and other joint tissues, and has a number of by Pelletier and coworkers [1]) and help to perpetuate the
underlying causes, including both biochemical and mechanical inflammatory process. NO has also long been considered to
factors. Although proinflammatory factors including nitric oxide be a catabolic factor that contributes to the OA disease
(NO) are associated with OA, there is recent evidence suggesting pathology by mediating a number of processes, including
that NO and its redox derivatives may also play protective roles in
apoptosis, and perpetuating the expression of proinflam-
the joint. However, the mechanisms that underlie the development
and progression of OA are not completely understood. Experi- matory cytoki
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