novel experimental and clinical therapeutic uses of low-molecular-weight heparinprotamine microparticles新颖的实验和临床治疗使用低分子量heparinprotamine微粒.pdfVIP
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novel experimental and clinical therapeutic uses of low-molecular-weight heparinprotamine microparticles新颖的实验和临床治疗使用低分子量heparinprotamine微粒
Pharmaceutics 2012, 4, 42-57; doi:10.3390/pharmaceutics4010042
OPEN ACCESS
pharmaceutics
ISSN 1999-4923
/journal/pharmaceutics
Review
Novel Experimental and Clinical Therapeutic Uses of
Low-Molecular-Weight Heparin/Protamine Microparticles
Satoko Kishimoto 1,2, Masayuki Ishihara 1,*, Megumi Takikawa 3, Yasutaka Mori 1,4,
1 1 5
Hidemi Hattori , Masanori Fujita and Shingo Nakamura
1 Research Institute, National Defense Medical College, 3-2 Namiki, Tokorozawa,
Saitama 359-8513, Japan; E-Mails: resbiom@ndmc.ac.jp (S.K.); resbiom4@ndmc.ac.jp (Y.M.);
h2@ndmc.ac.jp (H.H.); fujitama@ndmc.ac.jp (M.F.)
2 Research Fellow of the Japan Society for the Promotion of Science, Tokyo 102-8472, Japan
3 Department of Plastic Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa,
Saitama, 359-8513 Japan; E-Mail: dr22057@ndmc.ac.jp
4 Aeromedical Laboratory, Japan Air Self-Defense Force, 2-3 Inariyama, Sayama, Saitama 350-1394,
Japan
5 Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa,
Saitama 359-8513, Japan; E-Mail: snaka@ndmc.ac.jp
* Author to whom correspondence should be addressed; E-Mail: ishihara@ndmc.ac.jp;
Tel.: +81-429-95-1211; Fax: +81-429-91-1611.
Received: 1 December 2011; in revised form: 31 December 2011 / Accepted: 31 December 2011 /
Published: 11 January 2012
Abstract: Low-molecular-weight heparin/protamine microparticles (LMW-H/P MPs) were
produced as a carrier for heparin-binding growth factors (GFs) and for various adhesive
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