nf-kappab in rheumatoid arthritis a pivotal regulator of inflammation, hyperplasia, and tissue destructionnf-kappab在风湿性关节炎炎症的关键调节器,增生,和组织破坏.pdfVIP

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nf-kappab in rheumatoid arthritis a pivotal regulator of inflammation, hyperplasia, and tissue destructionnf-kappab在风湿性关节炎炎症的关键调节器,增生,和组织破坏.pdf

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nf-kappab in rheumatoid arthritis a pivotal regulator of inflammation, hyperplasia, and tissue destructionnf-kappab在风湿性关节炎炎症的关键调节器,增生,和组织破坏

Available online /content/3/4/200 Commentary NF-B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction Sergei S Makarov Center for Inflammatory Disorders, Thurston Arthritis Research Center, and Department of Endodontics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Correspondence: Sergei S Makarov, 4109 Thurston, CB 7280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7280, USA. Tel: +1 919 966 9565; fax: +1 919 966 1739; e-mail: smak@ Received: 2 January 2001 Arthritis Res 2001, 3:200–206 Revisions requested: 26 February 2001 This article may contain supplementary data which can only be found Revisions received: 6 March 2001 online at /content/3/4/200 Accepted: 8 March 2001 © 2001 BioMed Central Ltd Published: 26 March 2001 (Print ISSN 1465-9905; Online ISSN 1465-9913) Abstract The transcription factor NF-B has been well recognized as a pivotal regulator of inflammation in rheumatoid arthritis (RA), but recent developments revealed a broad involvement of NF-B in other aspects of RA pathology, including development of T helper 1 responses, activation, abnormal apoptosis and proliferation of RA fibroblast-like synovial cells, and differentiation and activation of bone resorbing activity of osteoclasts. In agreement with this, studies in animal models of RA have demonstrated the high therapeutic efficacy of specific inhibitors of NF-B pathway, indicating the feasibility