nitric oxide and cardiovascular effects new insights in the role of nitric oxide for the management of osteoarthritis一氧化氮和心血管影响的新见解的角色一氧化氮对骨关节炎的管理.pdfVIP
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nitric oxide and cardiovascular effects new insights in the role of nitric oxide for the management of osteoarthritis一氧化氮和心血管影响的新见解的角色一氧化氮对骨关节炎的管理
Available online /supplements/10/S2/S3
Review
Nitric oxide and cardiovascular effects: new insights in the role
of nitric oxide for the management of osteoarthritis
Isla S Mackenzie, Daniel Rutherford and Thomas M MacDonald
Hypertension Research Centre (HRC) and Medicines Monitoring Unit (MEMO), Division of Medicine and Therapeutics, University of Dundee, Dundee
DD1 9SY, UK
Corresponding author: Isla S Mackenzie, I.S.Mackenzie@dundee.ac.uk
Published: 17 October 2008 Arthritis Research Therapy 2008, 10(Suppl 2):S3 (doi:10.1186/ar2464)
This article is online at /supplements/10/S2/S3
© 2008 BioMed Central Ltd
Abstract Recently, NSAIDs (both traditional and cyclo-oxygenase
[COX]-2 selective) were linked to an increased incidence of
Nitric oxide (NO) is an important mediator in both health and
disease. In addition to its effects on vascular tone and platelet cardiovascular events, at least in patients at increased
function, it plays roles in inflammation and pain perception that may baseline cardiovascular risk [2-5]. The degree of the risk
be of relevance in osteoarthritis. Many patients with osteoarthritis associated with the various NSAIDs and the mechanisms
take nonsteroidal anti-inflammatory drugs (NSAIDs) long term for underlying the link with cardiovascular events are still being
pain control. Over recent years concern has been raised about the
investigated in large clinical trials. Findings to date h
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