p-aminoacetophenonic acids produced by a mangrove endophyte streptomyces sp. (strain hk10552)p-aminoacetophenonic酸产生的红树林内生植物链霉菌属sp(应变hk10552)。.pdf

Molecules 2010, 15, 2782-2790; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article p -Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552) Fangfang Wang 1,2, Minjuan Xu 1,3,*, Qingshan Li 2,*, Isable Sattler 4 and Wenhan Lin 1,2 1 State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China; E-Mails: fangfang70303@ (F.F.W.); whlin@ (W.L.) 2 School of Pharmaceutical Sciences, Shangxi Medical University, Shanxi 030001, China 3 Shanghai Center for Systems Biomedicine, Shanghai Jiaotong University, Shanghai 200240, China 4 Leibniz Institute for Natural Products Research and Infection Biology, Hans-Knöll Institute, Beutenbergstr.11a, D-07745 Jena, Germany; E-Mail: isattler@rhrk.uni-kl.de (I.S.) ∗ Author to whom correspondence should be addressed; E-Mails: minjuanxu@ (M.X.); qingshanl@ (Q.L.); Tel.: +86-010 Fax: +86-010 Received: 18 March 2010; in revised form: 31 March 2010 / Accepted: 6 April 2010 / Published: 16 April 2010 Abstract: Four new p -aminoacetophenonic acids, named (2E)-11-(4′-aminophenyl)-5,9- dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (1), 9-(4′-aminophenyl)-3,7- dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid (2), (2E)-11-(4′-aminophenyl)-5,9-O-cyclo- 4,6,8-trimethyl-11-oxo-undec-2-enoic acid (3) and 9-(4′-aminophenyl)-3,7-O-cyclo-2,4,6- trimethyl-9-oxo-nonoic acid (4), were isolated from an endophyte Streptomyces sp. (strain HK10552) of the