palyosulfonoceramides a and b unique sulfonylated ceramides from the brazilian zoanthids palythoa caribaeorum and protopalyhtoa variabilisa和b palyosulfonoceramides独特sulfonylated神经酰胺从巴西zoanthids palythoa caribaeorum和protopalyhtoa摘要.pdf

Mar. Drugs 2012, 10, 2846-2860; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Palyosulfonoceramides A and B: Unique Sulfonylated Ceramides from the Brazilian Zoanthids Palythoa caribaeorum and Protopalyhtoa variabilis 1 1 2 1 Jose Gustavo L. Almeida , Ana Isabel V. Maia , Diego V. Wilke , Edilberto R. Silveira , Raimundo Braz-Filho 1, James J. La Clair 3, Leticia V. Costa-Lotufo 2,* and 1 Otília Deusdenia L. Pessoa 1 Department of Organic and Inorganic Chemistry, Federal University of Ceara, Fortaleza, CE, 60021-970, Brazil; E-Mails: gugaufc@ (J.G.L.A.); isabelvmaia@ (A.I.V.M.); edil@ufc.br (E.R.S.); braz@uenf.br (R.B.-F.); opessoa@ufc.br (O.D.L.P.) 2 Department of Physiology and Pharmacology, Federal University of Ceara, Fortaleza, CE, 60430-270, Brazil; E-Mail: diegowilke@ 3 Xenobe Research Institute, P.O. Box 3052, San Diego, CA 92163, USA; E-Mail: i@ * Author to whom correspondence should be addressed; E-Mail: costalotufo@; Tel.: +55-85-3366-8201; Fax: +55-85-3366-8333. Received: 11 September 2012; in revised form: 19 November 2012 / Accepted: 3 December 2012 / Published: 14 December 2012 Abstract: The zoanthids Palythoa caribaeorum and Protopalythoa variabilis are among the most abundant marine species along the Brazilian coast. We now report the isolation and structure elucidation of two unprecedented sulfonylated ceramides, palyosulfonoceramide A (1) and paly