paper reports overview sepsis, insulin and noninvasive ventilation论文报告概述脓毒症、胰岛素和无创通气.pdf

Available online /content/6/1/093 Paper reports Synopses of recently published research relevant to intensivists 6 November 2001 – 8 January 2002 Overview Sepsis, insulin and noninvasive ventilation Richard Venn Critical Care 2002, 6:93-94 The paper reports presented here reflect the current leading pressure ventilation. Not surprisingly, the need for extubation issues in the intensive care literature, the search for the ‘magic was significantly higher in the control group, as was hospital bullet’ in sepsis being an obvious example. Many of the trials in and 120-day mortality. It would be interesting to know whether sepsis that are currently being reported were presented at this mortality benefit remained significant if the randomization recent conferences [1]. This is the case for the KyperSept had been to nonintermittent positive pressure ventilation versus Antithrombin III Study (see paper report) [2]. The summary of invasive ventilation. this paper highlights the disappointment of the study: “ATIII [antithrombin III] joins a long list of promising experimental Hormone therapy has always been popular in the critically ill, agents for sepsis that failed to show a significant benefit in a and one report [7] investigated intensive insulin therapy in non- multicentre, randomised phase III clinical trial.” diabetic surgical and critically ill patients. Crude hospital mor- tality was 7.2% in the intensive therapy group versus 10.9% in Although some success has been reported with ‘magic bullet’