paradoxical interplay of viral and cellular functions矛盾的相互作用的病毒和细胞功能.pdf

Viruses 2011, 3, 272-277; doi:10.3390/v3030272 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Commentary Paradoxical Interplay of Viral and Cellular Functions Esteban Domingo 1,2 1 Centro de Biología Molecular Severo Ochoa (CSIC-UAM), C/ Nicolás Cabrera, 1, Cantoblanco, Madrid 28049, Spain 2 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona 08036, Spain; E-Mail: edomingo@cbm.uam.es; Tel.: +34-91-1964540; Fax: +34-91-1964420 Received: 9 February 2011; in revised form: 3 March 2011 / Accepted: 7 March 2011 / Published: 15 March 2011 Abstract : Some cellular editing functions can restrict the replication of some viruses but contribute to completion of the life cycle of others. A recent study has identified an isoform of the adenosine deaminase acting on RNA type 1 (ADAR 1) as required for embryogenesis, and as a restriction factor for a number of important RNA virus pathogens [1]. The dual implication of key cellular functions in the innate immunity against viruses, or, paradoxically, as mediators of virus replication is interpreted in the light of the concept of virus-host coevolution and tinkering proposed for general evolution by François Jacob decades ago. Keywords: RNA virus; host-virus interaction; coevolution 1. Introduction A recent publication by M.B. Oldstone and colleagues at the Scripps Research Institute of La Jolla ha