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perturbations in the impact of mutational activity on vλ genes in systemic lupus erythematosus扰动的影响vλ基因突变活动系统性红斑狼疮.pdf

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perturbations in the impact of mutational activity on vλ genes in systemic lupus erythematosus扰动的影响vλ基因突变活动系统性红斑狼疮

Available online /content/3/6/368 Research article Perturbations in the impact of mutational activity on Vλλ genes in systemic lupus erythematosus Thomas Dörner*, Sabine Kaschner*, Arne Hansen*, Axel Pruss† and Peter E. Lipsky‡ *Department of Medicine and †Institute of Transfusion Medicine, University Hospital Charite, Berlin, Germany ‡National Institutes of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA Correspondence: Thomas Dörner, MD, Department of Medicine, University Hospital Charite, Schumannstr. 20/21, 10098 Berlin, Germany. Tel: +49 30 4505 13017; fax: +49 30 4505 13917; e-mail: thomas.doerner@charite.de Received: 15 May 2001 Arthritis Res 2001, 3:368-374 Revisions requested: 2 July 2001 This article may contain supplementary data which can only be found Revisions received: 10 August 2001 online at /content/3/6/368 Accepted: 24 August 2001 © 2001 Dörner et al, licensee BioMed Central Ltd Published: 14 September 2001 (Print ISSN 1465-9905; Online ISSN 1465-9913) Abstract To assess the impact of somatic hypermutation and selective influences on the Vλ light chain repertoire in systemic lupus erythematosus (SLE), the frequency and pattern of mutations were analyzed in individual CD19+ B cells from a patient with previously undiagnosed SLE. The mutational frequency of nonproductive and productive rearrangements in the SLE patient was greater (3.1 × 10–2 vs 3.4 × 10–2, respectively) than that