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phage display for the generation of antibodies for proteome research, diagnostics and therapy噬菌体展示抗体的生成的蛋白质组研究、诊断和治疗.pdf

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phage display for the generation of antibodies for proteome research, diagnostics and therapy噬菌体展示抗体的生成的蛋白质组研究、诊断和治疗

Molecules 2011, 16, 412-426; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Phage Display for the Generation of Antibodies for Proteome Research, Diagnostics and Therapy Thomas Schirrmann, Torsten Meyer, Mark Schütte †, André Frenzel and Michael Hust * Technische Universität Braunschweig, Institute of Biochemistry and Biotechnology, Department of Biotechnology, Spielmannstr. 7, 38106 Braunschweig, Germany † Present address: Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany * Author to whom correspondence should be addressed; E-Mail: m.hust@tu-bs.de. Received: 10 November 2010; in revised form: 4 January 2011 / Accepted: 7 January 2011 / Published: 10 January 2011 Abstract: Twenty years after its development, antibody phage display using filamentous bacteriophage represents the most successful in vitro antibody selection technology. Initially, its development was encouraged by the unique possibility of directly generating recombinant human antibodies for therapy. Today, antibody phage display has been developed as a robust technology offering great potential for automation. Generation of monospecific binders provides a valuable tool for proteome research, leading to highly enhanced throughput and reduced costs. This review presents the phage display technology, application areas of antibodies in research, diagnostics and therapy and the use of antibody phage display for these applications.