pharmacodynamic optimization of β-lactams in the patient care setting药效学的β-lactams优化病人护理设置.pdfVIP

Available online /content/12/S4/S2 Review Pharmacodynamic optimization of ββ-lactams in the patient care setting David P Nicolau Center for Anti-Infective Research and Development, Hartford Hospital, Seymour Street, Hartford, Connecticut 06102, USA Corresponding author: David P Nicolau, dnicola@ Published: 21 May 2008 Critical Care 2008, 12(Suppl 4):S2 (doi:10.1186/cc6818) This article is online at /content/12/S4/S2 © 2008 BioMed Central Ltd Abstract penicillin were recognized as producing high peak concen- trations that could not be maintained, whereas continuous In order to eradicate an infecting organism, it is necessary to achieve or maintain concentrations of an antibiotic in vivo that intravenous infusions produced constant and sustained exceed the minimum inhibitory concentration (MIC) for the concentrations of penicillin. However, continuous intravenous organism. Duration of exposure, or time above MIC, was infusions of antibiotics fell out of favor as a treatment strategy. recognized as being important for β-lactam antibiotics more than Contributing to the shift in antibiotic administration regimens 60 years ago. Continuous infusion regimens are associated with were a more plentiful drug supply, the convenience of higher clinical response rates, improvement in surrogate markers of outcome, and lower cost of therapy compa