原创力文档pasteurella multocida toxin activates various heterotrimeric g proteins by deamidation巴斯德菌multocida毒素激活各种heterotrimeric g蛋白脱酰氨基作用.pdfVIP
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pasteurella multocida toxin activates various heterotrimeric g proteins by deamidation巴斯德菌multocida毒素激活各种heterotrimeric g蛋白脱酰氨基作用
Toxins 2010, 2, 205-214; doi:10.3390/toxins2020205
OPEN ACCESS
toxins
ISSN 2072-6651
/journal/toxins
Review
Pasteurella multocida Toxin Activates Various Heterotrimeric G
Proteins by Deamidation
Joachim H. C. Orth and Klaus Aktories *
Institute for Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, 79104
Freiburg, Germany; E-Mail: Joachim.Orth@pharmakol.uni-freiburg.de
* Author to whom correspondence should be addressed;
E-Mail: Klaus.Aktories@pharmakol.uni-freiburg.de; Tel.: +49-761-203-5301;
Fax: +49-761-203-5311.
Received: 24 November 2009; in revised form: 19 January 2010 / Accepted: 27 January 2010 /
Published: 28 January 2010
Abstract: Pasteurella multocida produces a 146-kDa protein toxin (Pasteurella multocida
toxin, PMT), which stimulates diverse cellular signal transduction pathways by activating
heterotrimeric G proteins. PMT deamidates a conserved glutamine residue of the α-subunit
of heterotrimeric G proteins that is essential for GTP-hydrolysis, thereby arresting the G
protein in the active state. The toxin substrates are Gα Gα and the Gα-family proteins.
q 13 i
Activation of these α-subunits causes stimulation of phospholipase Cβ, Rho-guanine
nucleotide exchange factors or inhibition of adenylyl cyclase. This article provides the
current knowledge on PMT concerning the structure-function analysis based on the crystal
structure and rece
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