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pathogenesis of hepatitis c during pregnancy and childhood怀孕期间的丙型肝炎发病机理和童年
Viruses 2012, 4, 3531-3550; doi:10.3390/v4123531
OPEN ACCESS
viruses
ISSN 1999-4915
/journal/viruses
Review
Pathogenesis of Hepatitis C During Pregnancy and Childhood
Armelle Le Campion 1, Ariane Larouche 1,2, Sébastien Fauteux-Daniel 1,2
and Hugo Soudeyns 1,2,3,*
1 Unité d’immunopathologie virale, Centre de recherche du CHU Sainte-Justine,
3175 Côte Sainte-Catherine, local 6735, Montreal, Quebec, H3T 1C5, Canada;
E-Mails: a.le.campion@umontreal.ca (A.L.C); ariane.larouche@umontreal.ca (A.L.);
fauteux.sebastien@ (S.F.-D.)
2 Department of Microbiology Immunology, Faculty of Medicine, Université de Montréal,
C.P. 6128, Succ. Centre-ville, Montreal, Quebec, H3C 3J7, Canada
3 Department of Pediatrics, Faculty of Medicine, Université de Montréal, C.P. 6128,
Succ. Centre-ville, Montreal, Quebec, H3C 3J7, Canada
* Author to whom correspondence should be addressed; E-Mail: hugo.soudeyns@recherche-ste-
justine.qc.ca; Tel.: +1 514 345-4931 Ext. 3907; Fax: +1 514 345-4794.
Received: 2 November 2012; in revised form: 18 November 2012 / Accepted: 28 November 2012 /
Published: 6 December 2012
Abstract: The worldwide prevalence of HCV infection is between 1% and 8% in pregnant
women and between 0.05% and 5% in children. Yet the pathogenesis of hepatitis C during
pregnancy and in the neonatal period remains poorly understood. Mother-to-child
transmission (MTCT), a leading cause of pediatric HCV infection, takes place at a rate of
10%. Factors that increase the risk of MTCT include high maternal HCV viral load and
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