pharmacogenomic identification of c-mycmax-regulated genes associated with cytotoxicity of artesunate towards human colon, ovarian and lung cancer cell lines药物基因组学的识别c-mycmax-regulated基因与细胞毒性有关青蒿琥酯对人类结肠癌、卵巢癌和肺癌细胞系.pdfVIP

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pharmacogenomic identification of c-mycmax-regulated genes associated with cytotoxicity of artesunate towards human colon, ovarian and lung cancer cell lines药物基因组学的识别c-mycmax-regulated基因与细胞毒性有关青蒿琥酯对人类结肠癌、卵巢癌和肺癌细胞系.pdf

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pharmacogenomic identification of c-mycmax-regulated genes associated with cytotoxicity of artesunate towards human colon, ovarian and lung cancer cell lines药物基因组学的识别c-mycmax-regulated基因与细胞毒性有关青蒿琥酯对人类结肠癌、卵巢癌和肺癌细胞系

Molecules 2010, 15, 2886-2910; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Pharmacogenomic Identification of c-Myc/Max-Regulated Genes Associated with Cytotoxicity of Artesunate towards Human Colon, Ovarian and Lung Cancer Cell Lines Serkan Sertel 1,2,3, Tolga Eichhorn 2,3, Christian H. Simon 1, Peter K. Plinkert 1, Steven W. Johnson 4 and Thomas Efferth 2,3,* 1 Department of Otorhinolaryngology, Head Neck Surgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany 2 German Cancer Research Center, Pharmaceutical Biology (C015), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany 3 Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudingerweg 5, 55099 Mainz, Germany 4 Department of Pharmacology, University of Pennsylvania Cancer Center, Philadelphia, PA 19104- 6160, USA * Author to whom correspondence should be addressed; E-Mail: efferth@uni-mainz.de. Received: 26 March 2010; in revised form: 20 April 2010 / Accepted: 22 April 2010 / Published: 22 April 2010 Abstract: Development of novel therapy strategies is one of the major pressing topics of clinical oncology to overcome drug resistance of tumors. Artesunate (ART) is an anti- malarial drug, which also exerts profound cytotoxic activity towards cancer cells. We applied a gene-hunting approach using microarray-based transcriptome-wide mRNA expression profiling and COMPARE analyse