pharmacophore and molecular docking guided 3d-qsar study of bacterial enoyl-acp reductase (fabi) inhibitors药效基因和分子对接指导3 d-qsar研究细菌enoyl-acp还原酶(fabi)抑制剂.pdfVIP
- 1、本文档共19页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
pharmacophore and molecular docking guided 3d-qsar study of bacterial enoyl-acp reductase (fabi) inhibitors药效基因和分子对接指导3 d-qsar研究细菌enoyl-acp还原酶(fabi)抑制剂
Int. J. Mol. Sci. 2012, 13, 6620-6638; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Pharmacophore and Molecular Docking Guided 3D-QSAR
Study of Bacterial Enoyl-ACP Reductase (FabI) Inhibitors
Xiaoyun Lu 1,2,*, Man Lv 1, Kun Huang 2, Ke Ding 1 and Qidong You 2
1 Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institutes
of Biomedicine and Health, Chinese Academy of Sciences, No. 190, Kaiyuan Avenue, Science Park,
Guangzhou 510530, China; E-Mails: lv_man@ (M.L.); ding_ke@ (K.D.)
2 Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing
210009, China; E-Mails: huangkun0214888@ (K.H.); youqidong@ (Q.Y.)
* Author to whom correspondence should be addressed; E-Mail: lu_xiaoyun@;
Tel.: +86-020 Fax: +86-020
Received: 20 March 2012; in revised form: 7 May 2012 / Accepted: 14 May 2012 /
Published: 30 May 2012
Abstract: Enoyl acyl carrier protein (ACP) reductase (FabI) is a potential target for the
development of antibacterial agents. Three-dimensional quantitative structure-activity
relationships (3D-QSAR) for substituted formamides series of FabI inhibitors were
investigated using comparative molecular field analysis (CoMFA) and comparative
molecular similarity indices analysis (CoMSIA) techniques. Pharmacophore and molecular
docking methods were used for construc
您可能关注的文档
- patient preferences for emergency department-initiated tobacco interventions a multicenter cross-sectional study of current smokers病人偏好紧急了烟草干预吸烟者的多中心横断面研究.pdf
- patient safety and acute care medicine lessons for the future, insights from the past患者安全为未来和急症护理医学课程,从过去的见解.pdf
- patient- and population-level health consequences of discontinuing antiretroviral therapy in settings with inadequate hiv treatment availability病人和全民健康后果设置中断抗逆转录病毒治疗的艾滋病毒治疗不足的可用性.pdf
- patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care病人安全简单的偏好和治疗酵母菌病在初级卫生保健.pdf
- pathogenic mechanisms of idiopathic nonallergic rhinitis特发性nonallergic鼻炎的致病机制.pdf
- pathway analysis of the transcriptome and metabolome of salt sensitive and tolerant poplar species reveals evolutionary adaption of stress tolerance mechanisms通路分析转录组和代谢组的盐敏感和宽容揭示杨树物种进化适应压力的耐受机制.pdf
- patient-oriented gene set analysis for cancer mutation datapatient-oriented癌症突变基因集合分析数据.pdf
- patients' opinion on the barriers to diabetes control in areas of conflicts the iraqi example糖尿病控制障碍病人的意见冲突地区的伊拉克的例子.pdf
- patient safety in pre-hospital emergency tracheal intubation a comprehensive meta-analysis of the intubation success rates of ems providers在院前紧急气管插管患者安全的全面分析ems提供商的插管成功率.pdf
- patients' perceptions of safety and quality of maternity clinical handover病人的安全和质量感知的产科临床交接.pdf
- DB22_T2381-2015_中华绒螯蟹盐碱沼泽生态养殖技术规范_吉林省.docx
- DB22_T2153-2014_草型湖泊河蟹生态养殖技术规程_吉林省.docx
- DB22_T2262-2015_绿化树木移植技术规程_吉林省.docx
- DB22_T1856-2013_卷烟生产企业单位产品综合电耗限额_吉林省.docx
- DB22_T2355-2015_薄皮甜瓜品种吉丰花冠_吉林省.docx
- DB22_T2406-2015_糖尿病前期的管理规范_吉林省.docx
- DB22_T2147-2014_油用型向日葵杂交种种子质量_吉林省.docx
- DB22_T2196-2014_血液透析用水及血液透析液质量监控规范_吉林省.docx
- DB22_T2036-2014_泥炭的应用分类_吉林省.docx
- DB22_T2201-2014_社区卫生机构首诊服务规范_吉林省.docx
最近下载
- 检验医学室内质控图模板.xls VIP
- 酒店工程部服务意识培训.ppt
- 2014款雷克萨斯CT200h_汽车使用手册用户操作图示驾驶指南车主车辆说明书电子版.pdf
- SMED快速换模完整.doc VIP
- 《婴幼儿回应性照料》第八讲.pptx VIP
- 乳胶漆施工工艺55页课件.ppt VIP
- 最新人教版九年级数学上册-全册课件全集(1215张).pptx VIP
- 2025至2030中国村镇银行行业深度分析及发展前景与发展战略报告.docx
- JTG D 20-2017公路路线设计规范_(高清版).pdf VIP
- 道奇-JCUV-产品使用说明书-Journey Crossroad 旅行版(2.4L)-JCUV (B6F)-2013款酷威用户手册(产品使用说明书).pdf VIP
文档评论(0)